New master’s student in the ART future project

Starting in September this year, a new master’s student, Anna Kolesnik, will join the Future of Assisted Reproduction (ART) project (AV21 Strategy). Anna is enrolled in the Reproductive and Developmental Biology program at the Faculty of Science, Charles University. In her master’s thesis, she will focus on the study of the spindle apparatus in early embryos.

In Martin Anger’s laboratory, within the topic Cell Cycle at Life's Start, she will investigate the causes of abnormal spindle activity. The aim of her work is to clarify how the SAC (spindle assembly checkpoint) regulates the activity of the APC/C (anaphase-promoting complex) and how such changes are reflected in spindle function. The results will deepen our understanding of the causes of aneuploidy in mammalian embryos. Aneuploidy is an incorrect number of chromosomes, that is one of the main causes of miscarriages and congenital developmental disorders in humans.

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