Martin Anger

Doc. MVDr. Martin Anger, CSc. received his PhD. from Academy of Sciences in 2001. Subsequently he assumed postdoctoral positions at the University of Philadelphia, then at Research institute of molecular Pathology in Vienna and finally at the University of Oxford. For his research he obtained support from Marie Curie actions (Marie Curie Individual Fellowship, Marie Curie Reintegration grant), EMBL (EMBO installation grant) a Czech Academy of Sciences (Purkyně fellowship). In 2011 he established Laboratory of cell division control at Institute of Animal Physiology and Genetics, Czech Academy of Sciences.

Research in his laboratory is focused on chromosome segregation during mammalian early development. Incorrect chromosome segregation frequently leads into aneuploidy, which is the most frequent cause of termination of development and embryo loss in mammals. Specifically, he aims to understand the role of cell cycle checkpoints during early development, which exhibit important functional differences in comparison to the somatic cells.

The research within the project ART – future of assisted reproduction in Martin Anger’s laboratory will be focused on driving forces of the cell cycle, namely on complexes of cyclins and cyclin dependent kinases (CDKs), as well as on key factors controlling chromosome segregation, namely the activity of Anaphase Promoting Complex/Cyclosome and Spindle Assembly Checkpoint (SAC) in meiosis and early mitotic divisions in the embryo. The aim will be to understand the role of cell cycle control mechanisms in the origin of aneuploidy and the possibilities of their corrections to improve early development.

https://www.iapg.cas.cz/cs/laboratore/lab-kontroly-bunecneho-deleni/vyzkum/