Andrej Šušor

Ing. Andrej Šušor, Ph.D. received his doctorate from Charles University in 2008 and subsequently completed a research internship at the University of California, San Francisco. Since 2017, he has headed the Laboratory of Biochemistry and Molecular Biology of Germ Cells at the Institute of Animal Physiology and Genetics of the Czech Academy of Sciences. His work was supported by the GAČR program.

Research in his laboratory focuses on the regulation of protein synthesis during oocyte maturation and early embryonic development. Errors in chromosome segregation often lead to aneuploidy, the main cause of early developmental arrest and infertility in mammals. The team is also investigating translation factors that are crucial for the development of mammalian germ cells and embryos, which have functional differences compared to somatic cells.

As part of the ART Future project, the lab will investigate the activity of the translational machinery, which consists of ribosomes and associated regulatory factors, as well as the key signalling pathways that control protein expression. The research will address how these regulatory mechanisms contribute to infertility, how their functions change during early development and what possibilities exist to restore their activity in cases of dysfunction.

https://www.iapg.cas.cz/en/laboratories/lbmbzb/Research/index.html